There are over-the-counter and prescription medications that help people manage sciatica pain. Over-the-counter medications include aspirin, acetaminophen, NSAIDs, and naproxen. Prescription medications include muscle relaxants, antidepressants, and pain medication. However, some people use medications only as a last resort.
The most effective non-medication pain management approach is doing exercises that target sciatic nerve pain, such as stretching, walking, and exercises that improve core muscle strength. A doctor may recommend seeing a physical therapist who can teach you the best practices for sciatic nerve pain.